GIFT Faculty
Weidong Li
Professor, Global Institute of Future Technology, Shanghai Jiao Tong University
Department of Medicine, Shinshu University, Japan
Postdoc., UCLA, USA
Office Location :Global Institute of Future Technology, SJTU
Tel :021-54741175
Email :liwd@sjtu.edu.cn
Education

1997,Department of Medicine, Shinshu University, Japan,Doctor

1990,China Medical University,Bachelor

Work Experience

2023-Pres.,Global Institute of Future Technology, SJTU,Professor

2021-Pres.,Institute of Psychology and Behavioral Sciences of SJTU,Executive Dean

2020-Pres.,SJTU,Tenured professor

2016-2021,Research Management Division, SJTU,Deputy Dean

2015-Pres.,Brain Science and Technology Research Center of SJTU,Executive Director

2013-Pres.,Bio-X Research Institute of SJTU,Researcher and vice president

2009-2013,Bio-X Institute of SJTU,Special researcher and dean assistant

2007-2010,Department of Neurobiology, UCLA, USA,Assistant Researcher

2002-2007,Department of Neurobiology and Psychology, UCLA, USA,Postdoctoral Researcher

2001-2002,Department of Neuroplasticity, Shinshu University School of Medicine,Instructor

1996-1997,China-Japan Friendship Hospital, Beijing, China,Residency

Research Fields

Neural mechanism of negative emotional memory and forgetting

Pathogenesis and treatment of depression

Establishment of non-human primate epilepsy model and its pathogenesis

Epigenetic research on learning and memory

Brain mechanism of psychological laws

Honors and Awards

2021,GF Science and Technology Innovation Center excellent researchers (national level)

2021,Foreign academician of Ukrainian National Academy of Engineering

2019,Chief scientist of National 173 Key Program

2018,Outstanding Contribution Title of World Top Scientists Forum

2017,Advanced Individual in Social Service of the Shanghai Municipal Committee of the Democratic League of China

2017,Shanghai Excellent Academic Leader

2016,SJTU Foreign Affairs Advanced Worker

2016,Activist of “love the League and respect the education”, China Democratic League SJTU Committee

2015,China Industry-University-Research Cooperation Innovation Award

2014,Eastern Scholar Tracking Program

2011,Talent of Shanghai Pujiang Program

2010,Eastern Scholar at Shanghai Institutions of Higher Learning

2010,Shanghai “Shu Guang” Scholar

2008,Young Investigator Award, Children’s Tumor Foundation (CTF)

2007,Young Investigator Award, (NARSAD)

2006,NARSAD Daniel X. Freedman Investigator

2005,Young Investigator Award, National Alliance for Research on Schizophrenia and Depression (NARSAD)

Scientific research project

    2023-2026: Shanghai Municipal Science and Technology Commission Intergovernmental Cooperation Project, Research on Neural Network Mechanisms of Memory Impairment Animal Models, Principal Investigator.

    2022-2025: Ministry of Science and Technology 2030 National Science and Technology Major Project, Research on the Neural Mechanisms of Long-term Memory Encoding, Decay, and Elimination, Participant, Project Leader.

    2022-2024: Shanghai Municipal Science and Technology Commission Project, Genetic Mechanisms and Neurobiological Research of Primary Epilepsy in Marmoset Families - Matching Host, Principal Investigator.

    2021-2024: Shanghai Municipal Science and Technology Commission Project, Brain-Machine Interface System, Participant, Project Leader.

    2020-2021: Provincial and Municipal Project, Research on Neural Network Structure of Epileptic Marmosets, Principal Investigator.

    2020-2021: Ministry of Science and Technology Project, Genetic Mechanisms and Neurobiological Research of Primary Epilepsy in Marmoset Families, Principal Investigator.

    2019-2023: Shanghai Municipal Education Commission Project, Research on Genetic and Environmental Mechanisms of Depression and Model Organisms, Principal Investigator.

    2017-2020: Shanghai Municipal Science and Technology Commission Project, Research on the Mechanism of Decay in Negative Emotion Memory, Principal Investigator.

    2017-2019: National Natural Science Foundation Project, Research on Neural Circuits of Forgetting Mechanisms in Negative Emotion Memory, Principal Investigator.

    2016-2017: Shanghai Municipal Science and Technology Commission Project, Establishing a Schizophrenia Susceptibility Gene B-cell Lymphoma Factor 9 Mouse Model to Study Its Neurodevelopmental and Behavioral Abnormalities Mechanism, Principal Investigator.

    2014-2017: Shanghai Municipal Science and Technology Commission Project, Research on the Neural Circuit Mechanism of Emotional Memory Abnormalities Caused by Specific Knockdown of DISC1 Gene in Hippocampal Newborn Neurons, Principal Investigator.

    2013-2015: Key Laboratory Open Fund Project, The Impact of Environmental Stress on Cognitive Ability and Its Neural Mechanisms, Principal Investigator.

    2013-2015: Ministry of Education Project, Research on the Pathogenesis of Schizophrenia Using DISC1 Gene Mouse Models and Gene Silencing Techniques, Principal Investigator.

    2013-2016: National Natural Science Foundation Project, Research on the Role of Ras-MAPK Signaling Pathway in Attention Deficit Hyperactivity Disorder Using Light-Controlled shRNA-NF1 Gene-Specific Knockdown Mice, Principal Investigator.

    2011-2013: Shanghai Municipal Science and Technology Commission Project, Research on the Mechanism by Which Specific Knockdown of DISC1 Gene in Adult Hippocampal Newborn Neurons Leads to Schizophrenia-related Behavioral Abnormalities, Principal Investigator.

    2011-2012: Shanghai Municipal Education Commission Project, Using DISC1 Knock-down Retrovirus to Study the Role of Hippocampal Neurogenesis in the Pathogenesis of Schizophrenia and Depression, Principal Investigator.

    2010-2015: Research on Neurodevelopmental and Behavioral Basis of Schizophrenia Animal Models, Participant, Project Leader.

    2010-2014: Shanghai Municipal Science and Technology Commission Project, Research on Neurodevelopmental and Behavioral Basis of Schizophrenia Animal Models, Principal Investigator.

Professional Service

2014 - 2020 Member of the Cognitive Neurobiology Branch of the Chinese Academy of Neuroscience

2014 - Pres. Editorial Board of Molecular Brain

2017 - 2020 Member of the Academic Committee of Shanghai Key Laboratory of Severe Psychosis

2018 - Pres. Director of Shanghai Neuroscience Society

2018 - Pres. Deputy Editor-in-chief of Neurology of Learning and Memory

2018 - Pres. Director of Molecular and Cellular Cognition Society (MCCS, Molecular and Cellular Cognition Society), Secretary General of MCCS Asia

2018 - Pres. Director of the Chinese Society of Neuroscience

2018 - Pres. Executive Chairman of the Young Scientists Forum of the World Top Scientists Association from

2019 - 2022 Expert Group of Shanghai Brain Science and Brain-like Research Center

2019 - Pres. Deputy Director and Secretary-General of the Learning and Memory Foundation and Clinical Branch of the Chinese Society of Neuroscience

2020 - Pres. Director of Shanghai Neuroscience Society

2021 - Pres. Member of the Psychological Committee of the World Top Scientists Association

2018 - Pres. Member of the Psychology Teaching Working Committee of the Chinese Psychological Society

2018 - 2021 Academic consultant of the World Top Scientists Forum

2018 - Pres. Executive Director of Brain Science and Technology Research Center of SJTU

2012 - Pres. Project Leader of Key Laboratory of the Ministry of Education

Selected Publications (10 selected in last 3 years)

Chen L, Li Y, Liu M, Lan Z, Zhang X, Yang X, Zhao Q, Wang S, Xu L, Zhou Y, Kuang Y, Suzuki T, Tabuchi K, Takahashi E, Zhou M, Chen CD, Xu T, Li W*. Desipramine reverses remote memory deficits by activating calmodulin-CaMKII pathway in a UTX knockout mouse model of Kabuki syndrome. Gen. Psychiatry. 2024;37(5):e101430.

Xu S, Liu Y, Lee H, Li W*. Front Cover: Neural interfaces: Bridging the brain to the world beyond healthcare. Explor. 2024;5(2):e101430.

Ma D, Kuang Y*, Lan Z, Zeng S, Li Y, Shang M, Zhang R-Y, Zhao B* and Li W*. The rapid change in mental health among college students after introduction of on-campus quarantine during the 2022 Shanghai COVID-19 lockdown. Front. Public Health.2023 May 5, 11:1132575.

Li W # *, Frank E#,Zhao Z#,Chen L, Wang Z, Burmeister M, Sen S*. Mental Health of Young Physicians in China During the Novel Coronavirus Disease 2019 Outbreak. JAMA network open. 2020, 3(6), pp. e2010705.[highlighted by AAAS EurekAlert!]

Chen X, Wang S,Zhou Y,Han Y, Li ST,Xu Q, Xu L, Zhu Z, Deng Y, Yu L,Song L, Chen AP, Song J, Takahashi E, He G, He L, Li W*, Chen CD*. Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway. Nat Commun. 2018 Jan 9;9(1):114.

Bao H#, Asrican B#, Li W#, Gu B, Wen Z, Lim SA, Haniff I, Ramakrishnan C, Deisseroth K, Philpot B, Song J. Long-Range GABAergic Inputs Regulate Neural Stem Cell Quiescence and Control Adult Hippocampal Neurogenesis. Cell Stem Cell. 2017 Nov 2;21(5):604-617.

Chu X, Zhou Y, Hu Z, Lou J, Song W, Li J, Liang X, Chen C, Wang S, Yang 1, Chen L, Zhang X, Song J, Dong Y, Chen S, He L, Xie Q*, Chen X*, Li W*. 24-hour-restraint stress induces long-term depressive-like phenotypes in mice. Sci Rep. 2016 Sep 9;6:32935.

Zhou M#, Li W # *, Huang S, Song J, Kim JY, Tian X, Kang E, Sano Y, Liu C, J. Balaji, Wu S, Zhou Y, Zhou Y, Parivash SN, Ehninger D, He L, Song H, Ming G-L, Silva AJ*. mTOR Inhibition Ameliorates Cognitive and Affective Deficits Caused by Disc1 Knockdown in Adult-Born Dentate Granule Neurons. Neuron. 2013 Feb 20;77(4):647-754.

Li W, Zhou Y, Jentch JD, Brown AM, Tian XL, Ehninger D, Hennah W, Peltonen, Lonnqvist J, Huttunen MO, Kaprio J, Trachtenberg JT, Silva AJ, Cannon TD. Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice. Proc Natl Acad Sci. 2007 Nov 13;104(46):18280-5.

Li W, Cui Y, Kushner SA, Brown AM, Jentsch JD, Frankland PW, Cannon TD, Silva AJ*. The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1. Curr Biol. 2005;15(19):1760-1764.

Course Taught (Recent 5 Years)

The Mysteries of Brain and Mental Health

Truth of Brain

Animal model application of optogenetics, transparent brain and brain imaging technology

Genetic Development and Psychoneurological Diseases

Neurobiology

Discussion Course of Molecular Biology

Molecular Biology

Genetics and Development