Lan Zhaohui is an Assistant Researcher and Master's Supervisor at Golbal Institute of Future Technology, Shanghai Jiao Tong University. Primary research focuses on: 1) the mechanisms of memory storage, investigating the neural circuits which are responsible for memory formation and storage in the brain using electrophysiology and optogenetics manipulate specific neuronal activity, elucidating the neurobiological mechanisms of memory encoding and consolidation; 2) the pathogenesis of neurodegenerative diseases, exploring the underlying mechanisms of these diseases through animal models and cellular experiments to reveal key molecular events during disease progression. we also develops brain modulation devices to explore novel therapeutic approaches for neurodegenerative diseases; 3) the development of novel drug delivery systems, designing targeted and biocompatible delivery carriers to enhance drug accumulation and targeting in the central nervous system. We has applied for over ten patents, with six granted, covering areas such as brain-machine interfaces and brain modulation. We published more than ten papers as the first or corresponding author in SCI journals including Ann. Neuro. (2024), Neuropathol Appl Neurobiol. (2024), Cell Rep. (2022), Transl. Res. (2023), and Gen. Comp. Endocrinol. (2021). We also has hosted and participated in numerous national and provincial research projects.

2018，Shanghai Ocean University，Ph.D

2015，Shanghai Ocean University，Master

2013，Jiangxi Agricultural University，Bachelor

2023-Pres.，Shanghai Jiaotong University,Global Institue of Future Technology，Assistant Researcher

2020-2023，Shanghai Jiaotong University,Bio-X institutes，Postdoc

2019-2020，UC Davis school of Medicine，Postdoc

2015，The “Challenge Cup” (the third prize 2015)

2016，China Innovation & Entrepreneurship Competition (2016&2017 the third prize)

Establishment of 24-hour Restraint mouse model and research on its electrophysiological mechanism, New faculty start-up project

Scientific and Technological Innovation 2030- “Brain Science and Brain-inspired Research” major project, research on the relationship and neural mechanisms of generalization, forgetting and erasure of long-term memory

C.X. Chen+1, Z.H. Lan+1, X.H. Tang, W. Chen, X. Zhou, H. Su, R.X. Su, Z.L. Chen, Y. Guo, W.B. Deng. Human-Derived Induced GABAergic Progenitor Cells Improve Cognitive Function in Mice and Inhibit Astrocyte Activation with Anti-Inflammatory Exosomes [J]. Ann Neurol, 2024, 96:488-507.

C.X. Chen+1, X.H. Tang+1, Z.H. Lan+1, W. Chen, Y. Guo, H. Su, W.D. Li, Y.X. Li, X. Zhou, H. Gao, X.W. Feng, M.C. Yao, W.B Deng*. Abnormalities of GABAergic signaling in Alzheimer’s disease with CLU mutation.Transl. Res. 2023.S1931-5244(23)

XD Ma+1, ZH Lan+1, ZT Chen, XY He, WD Li*. Significant Retest Effects in Spatial Working Memory Task 2023/03, J Shanghai Jiaotong Univ Sci. 2023.

Y Wang+1, S Zhang+1, ZH Lan+1, Vui D, K Bokyung, SH Liu, MN Zhu, VL Hull, S Rihani, CL Zhang, JA Gray, FZ Guo*. SOX2 is essential for astrocyte maturation and its deletion leads to hyperactive behavior in mice. Cell Rep. 2022.36543123

ZH Lan, W Zhang, JL Xu, WQ Lu*. GABAA receptor-mediated inhibition of Dahlgren cells electrical activity in the olive flounder, Paralichthys olivaceus. Gen. Comp. Endocrinol. 2021.33711316

M.N. Zhu, ZH Lan+1, J.Y. Park, Y. Wang, F.Z. Guo. Regulation of CNS pathology by Serpina3n /SERPINA3: The knowns and the puzzles, Neuropathol Appl Neurobiol, 50:e1290 2024.

Z Sheng, B Kim, XQ Zhu, W Yan, ZH Lan, P Preeti, F Kenneth, AJ Wang, FZ Guo*. Glial type specific regulation of CNS angiogenesis by HIFα-activated different signaling pathways. Nat. Commun. 2020.32332719

ZH Lan+1, JL Xu+1, YJ Wang, WQ Lu*. Modulatory effect of glutamate GluR2 receptor on the caudal neurosecretory Dahlgren cells of the olive flounder, Paralichthys olivaceus. Gen. Comp. Endocrinol. 2018. 29355533

ZH Lan+1, W Zhang+1, JL Xu, M Zhou, YX Chen, HF Zou, WQ Lu*. Modulatory effect of dopamine 5 on the caudal neurosecretory Dahlgren cells of the olive flounder, Paralichthys olivaceus. Gen. Comp. Endocrinol. 2018. 29678723

+1 represent equally contribution