Personal Profile
Education
1997 Department of Medicine, Shinshu University, Japan Doctor
1990 China Medical University Bachelor
Work Experience
2023 - pres. Global Institute of Future Technology, SJTU Professor
2021 - pres. Institute of Psychology and Behavioral Sciences of SJTU Executive Dean
2020 - pres. SJTU Tenured professor
2016 - 2021 Research Management Division, SJTU Deputy Dean
2015 - pres. Brain Science and Technology Research Center of SJTU Executive Director
2013 - pres. Bio-X Research Institute of SJTU Researcher and vice president
2009 - 2013 Bio-X Institute of SJTU Special researcher and dean assistant
2007 - 2010 Department of Neurobiology, UCLA, USA Assistant Researcher
2002 - 2007 Department of Neurobiology and Psychology, UCLA, USA Postdoctoral Researcher
2001 - 2002 Department of Neuroplasticity, Shinshu University School of Medicine Instructor
1996 - 1997 China-Japan Friendship Hospital, Beijing, China Residency
Research Fields
Neural mechanism of negative emotional memory and forgetting
Pathogenesis and treatment of depression
Establishment of non-human primate epilepsy model and its pathogenesis
Epigenetic research on learning and memory
Brain mechanism of psychological laws
Honors and Awards
2021 GF Science and Technology Innovation Center excellent researchers (national level)
2021 Foreign academician of Ukrainian National Academy of Engineering
2019 Chief scientist of National 173 Key Program
2018 Outstanding Contribution Title of World Top Scientists Forum
2017 Advanced Individual in Social Service of the Shanghai Municipal Committee of the Democratic League of China
2017 Shanghai Excellent Academic Leader
2016 SJTU Foreign Affairs Advanced Worker
2016 Activist of “love the League and respect the education”, China Democratic League SJTU Committee
2015 China Industry-University-Research Cooperation Innovation Award
2014 Eastern Scholar Tracking Program
2011 Talent of Shanghai Pujiang Program
2010 Eastern Scholar at Shanghai Institutions of Higher Learning
2010 Shanghai “Shu Guang” Scholar
2008 Young Investigator Award, Children’s Tumor Foundation (CTF)
2007 Young Investigator Award, (NARSAD)
2006 NARSAD Daniel X. Freedman Investigator
2005 Young Investigator Award, National Alliance for Research on Schizophrenia and Depression (NARSAD)
Scientific research project
2023-2026: Shanghai Municipal Science and Technology Commission Intergovernmental Cooperation Project, Research on Neural Network Mechanisms of Memory Impairment Animal Models, Principal Investigator.
2022-2025: Ministry of Science and Technology 2030 National Science and Technology Major Project, Research on the Neural Mechanisms of Long-term Memory Encoding, Decay, and Elimination, Participant, Project Leader.
2022-2024: Shanghai Municipal Science and Technology Commission Project, Genetic Mechanisms and Neurobiological Research of Primary Epilepsy in Marmoset Families - Matching Host, Principal Investigator.
2021-2024: Shanghai Municipal Science and Technology Commission Project, Brain-Machine Interface System, Participant, Project Leader.
2020-2021: Provincial and Municipal Project, Research on Neural Network Structure of Epileptic Marmosets, Principal Investigator.
2020-2021: Ministry of Science and Technology Project, Genetic Mechanisms and Neurobiological Research of Primary Epilepsy in Marmoset Families, Principal Investigator.
2019-2023: Shanghai Municipal Education Commission Project, Research on Genetic and Environmental Mechanisms of Depression and Model Organisms, Principal Investigator.
2017-2020: Shanghai Municipal Science and Technology Commission Project, Research on the Mechanism of Decay in Negative Emotion Memory, Principal Investigator.
2017-2019: National Natural Science Foundation Project, Research on Neural Circuits of Forgetting Mechanisms in Negative Emotion Memory, Principal Investigator.
2016-2017: Shanghai Municipal Science and Technology Commission Project, Establishing a Schizophrenia Susceptibility Gene B-cell Lymphoma Factor 9 Mouse Model to Study Its Neurodevelopmental and Behavioral Abnormalities Mechanism, Principal Investigator.
2014-2017: Shanghai Municipal Science and Technology Commission Project, Research on the Neural Circuit Mechanism of Emotional Memory Abnormalities Caused by Specific Knockdown of DISC1 Gene in Hippocampal Newborn Neurons, Principal Investigator.
2013-2015: Key Laboratory Open Fund Project, The Impact of Environmental Stress on Cognitive Ability and Its Neural Mechanisms, Principal Investigator.
2013-2015: Ministry of Education Project, Research on the Pathogenesis of Schizophrenia Using DISC1 Gene Mouse Models and Gene Silencing Techniques, Principal Investigator.
2013-2016: National Natural Science Foundation Project, Research on the Role of Ras-MAPK Signaling Pathway in Attention Deficit Hyperactivity Disorder Using Light-Controlled shRNA-NF1 Gene-Specific Knockdown Mice, Principal Investigator.
2011-2013: Shanghai Municipal Science and Technology Commission Project, Research on the Mechanism by Which Specific Knockdown of DISC1 Gene in Adult Hippocampal Newborn Neurons Leads to Schizophrenia-related Behavioral Abnormalities, Principal Investigator.
2011-2012: Shanghai Municipal Education Commission Project, Using DISC1 Knock-down Retrovirus to Study the Role of Hippocampal Neurogenesis in the Pathogenesis of Schizophrenia and Depression, Principal Investigator.
2010-2015: Research on Neurodevelopmental and Behavioral Basis of Schizophrenia Animal Models, Participant, Project Leader.
2010-2014: Shanghai Municipal Science and Technology Commission Project, Research on Neurodevelopmental and Behavioral Basis of Schizophrenia Animal Models, Principal Investigator.
Selected Publications (10 selected in last 3 years)
1. Chen L, Li Y, Liu M, Lan Z, Zhang X, Yang X, Zhao Q, Wang S, Xu L, Zhou Y, Kuang Y, Suzuki T, Tabuchi K, Takahashi E, Zhou M, Chen CD, Xu T, Li W*. Desipramine reverses remote memory deficits by activating calmodulin-CaMKII pathway in a UTX knockout mouse model of Kabuki syndrome. Gen. Psychiatry. 2024;37(5):e101430.
2. Xu S*, Liu Y, Lee H, Li W*. Front Cover: Neural interfaces: Bridging the brain to the world beyond healthcare. Explor. 2024;5(2):e101430.
3. Ma D, Kuang Y*, Lan Z, Zeng S, Li Y, Shang M, Zhang R-Y, Zhao B* and Li W*. The rapid change in mental health among college students after introduction of on-campus quarantine during the 2022 Shanghai COVID-19 lockdown. Front. Public Health.2023 May 5, 11:1132575.
4. Li W # *, Frank E#，Zhao Z#，Chen L, Wang Z, Burmeister M, Sen S*. Mental Health of Young Physicians in China During the Novel Coronavirus Disease 2019 Outbreak. JAMA network open. 2020, 3(6), pp. e2010705.[highlighted by AAAS EurekAlert!]
5. Chen X, Wang S，Zhou Y，Han Y, Li ST，Xu Q, Xu L, Zhu Z, Deng Y, Yu L，Song L, Chen AP, Song J, Takahashi E, He G, He L, Li W*, Chen CD*. Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway. Nat Commun. 2018 Jan 9;9(1):114.
6. Bao H#, Asrican B#, Li W#, Gu B, Wen Z, Lim SA, Haniff I, Ramakrishnan C, Deisseroth K, Philpot B, Song J. Long-Range GABAergic Inputs Regulate Neural Stem Cell Quiescence and Control Adult Hippocampal Neurogenesis. Cell Stem Cell. 2017 Nov 2;21(5):604-617.
7. Chu X, Zhou Y, Hu Z, Lou J, Song W, Li J, Liang X, Chen C, Wang S, Yang 1, Chen L, Zhang X, Song J, Dong Y, Chen S, He L, Xie Q*, Chen X*, Li W*. 24-hour-restraint stress induces long-term depressive-like phenotypes in mice. Sci Rep. 2016 Sep 9;6:32935.
8. Zhou M#, Li W # *, Huang S, Song J, Kim JY, Tian X, Kang E, Sano Y, Liu C, J. Balaji, Wu S, Zhou Y, Zhou Y, Parivash SN, Ehninger D, He L, Song H, Ming G-L, Silva AJ*. mTOR Inhibition Ameliorates Cognitive and Affective Deficits Caused by Disc1 Knockdown in Adult-Born Dentate Granule Neurons. Neuron. 2013 Feb 20;77(4):647-754.
9. Li W, Zhou Y, Jentch JD, Brown AM, Tian XL, Ehninger D, Hennah W, Peltonen, Lonnqvist J, Huttunen MO, Kaprio J, Trachtenberg JT, Silva AJ, Cannon TD. Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice. Proc Natl Acad Sci. 2007 Nov 13;104(46):18280-5.
10. Li W, Cui Y, Kushner SA, Brown AM, Jentsch JD, Frankland PW, Cannon TD, Silva AJ*. The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1. Curr Biol. 2005;15(19):1760-1764.
Professional Service
2014 - 2020 Member of the Cognitive Neurobiology Branch of the Chinese Academy of Neuroscience
2014 - Pres. Editorial Board of Molecular Brain
2017 - 2020 Member of the Academic Committee of Shanghai Key Laboratory of Severe Psychosis
2018 - Pres. Director of Shanghai Neuroscience Society
2018 - Pres. Deputy Editor-in-chief of Neurology of Learning and Memory
2018 - Pres. Director of Molecular and Cellular Cognition Society (MCCS, Molecular and Cellular Cognition Society), Secretary General of MCCS Asia
2018 - Pres. Director of the Chinese Society of Neuroscience
2018 - Pres. Executive Chairman of the Young Scientists Forum of the World Top Scientists Association from
2019 - 2022 Expert Group of Shanghai Brain Science and Brain-like Research Center
2019 - Pres. Deputy Director and Secretary-General of the Learning and Memory Foundation and Clinical Branch of the Chinese Society of Neuroscience
2020 - Pres. Director of Shanghai Neuroscience Society
2021 - Pres. Member of the Psychological Committee of the World Top Scientists Association
2018 - Pres. Member of the Psychology Teaching Working Committee of the Chinese Psychological Society
2018 - 2021 Academic consultant of the World Top Scientists Forum
2018 - Pres. Executive Director of Brain Science and Technology Research Center of SJTU
2012 - Pres. Project Leader of Key Laboratory of the Ministry of Education
Course Taught (Recent 5 Years)
The Mysteries of Brain and Mental Health
Truth of Brain
Animal model application of optogenetics, transparent brain and brain imaging technology
Genetic Development and Psychoneurological Diseases
Neurobiology
Discussion Course of Molecular Biology
Molecular Biology
Genetics and Development
