学术讲座：Ontogeny of hippocampus-dependent memory
主讲人：Paul Frankland, Ph.D.
Senior Scientist, Hospital for Sick Children
Professor, Departments of Psychology, Physiology, Institute of Medical Science, University of Toronto
Canada Research Chair in Molecular & Cellular Cognition
时间：9:00, December 1st, 2023 (Beijing Time)
地点：Room 202, Yue-Kong Pao Library's Annex
讲座摘要：
Memories for events (i.e., episodic memories) formed in early development differ from those in adulthood in at least two regards. First, these memories tend to be rapidly forgotten (i.e., infantile amnesia). Second, they tend to be less precise than those formed in adulthood (i.e., infantile generalization). My talk will focus on the neurobiological mechanisms that account for these different operating characteristics of episodic memory in the developing brain. With respect to infantile amnesia, our studies have shown that maturation of hippocampal and cortical circuits is necessary for the formation of enduring event memories. With respect to infantile generalization, our studies reveal that maturation of inhibitory microcircuits in the hippocampus are necessary for the formation of adult-like, precise memories for events.
主讲人简介：
Paul Frankland is a Senior Scientist in the program in Neurosciences & Mental Health at the Hospital for Sick Children. He holds a Canada Research Chair in Cognitive Neurobiology, and is a member of the Department of Psychology, Department of Physiology and Institute of Medical Science at the University of Toronto. He is a Fellow of the Royal Society of Canada, and a member of the Canadian Institute for Advanced Research (CIFAR) in the program for Child and Brain Development. His lab's research focuses on modeling cognitive function and dysfunction in mice. In particular, the lab is interested in understanding of systems consolidation, the role of adult neurogenesis in hippocampal memory function and forgetting, the identification and manipulation of memory engrams, and hippocampal memory development. He has published more than 148 SCI academic papers in journals including Nature (2), Science (6), Neuron (10), Nature Neuroscience (11) etc.
